Derek Shepherd’s 12 Most Romantic Moments on ‘Grey’s Anatomy,’ Ranked

Lauren Dehollogne March 23, 2025, 4:00 pm

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Ellen Pompeo, Patrick Dempsey in 'Grey's Anatomy' Season 5 — Randy Holmes / ABC / Everett Collection

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Need a pick-me-up? Maybe it’s time to binge Grey’s Anatomy from the beginning… again.

Granted, there are plenty of heartbreaking deaths, fraught relationships, and traumatic backstories, but the love story that developed between Derek Shepherd (Patrick Dempsey), aka McDreamy, and Meredith Grey (Ellen Pompeo) brought some light to the otherwise dark show.

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