11 of Karen’s Snarkiest Comebacks on ‘Will & Grace’ (PHOTOS)

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Will & Grace - Season 3
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“Because I’m a lady, assface.”

She never ceases to remind us all of her womanhood, even if unladylike. Hear her roar — of course, with a signature martini in hand.

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“They are like Siamese twins who are joined at their boring personalities.”

Karen never hides her opinions on title characters Will (Eric McCormack) and Grace (Debra Messing).

Will & Grace
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“Well, well, well. Look what the cat cleaned up, showered, exfoliated, powdered, lipsticked, Gucci’d and dragged in.”

She sure knows how to give a compliment.

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“I think the real mistake was when your father spotted your mother across a crowded swamp, dragged her back to his hut, and made you.”

When the wrong invitations for her birthday party get sent out, Karen’s wrath knows no bounds.

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“I’m too tired to slap you. Would you bash your face against my palm?”

No sleep for the fabulously wicked!

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“Oh God, did you rent Pretty Woman again? Face it Grace, the only things you and Julia Roberts have in common are horse teeth and bad taste in men.”

Karen shatters any hopes of a rom-com ending to Grace’s love life.

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“How did you hurt your back? Running away from good taste?”

Karen shows her own form of sympathy to Aunt Honey (Lainie Kazan).

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“Talk to the boob.”

We all know Karen loves her assets, especially when sassing her now-passed housekeeper, Rosario (Shelley Morrison).

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“Wow, ten years of game night. What a milestone. Maybe you should celebrate with a suicide pact.”

That’s one way to ring in an anniversary.

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“Oh hey! Somebody got flowers. Or as I like to call them, poor people jewelry.”

Grace’s bouquet smells a little less sweet after Karen points out its price.

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“Honey, you’re simple, you’re shallow, and you’re a common whore. That’s why we’re soulmates.”

Karen’s harsh sneers give way to her sentimental side for her friendship with Jack (Sean Hayes).

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The iconic Karen Walker (Megan Mullally) has become a meme sensation with her zippy zingers and fabulously cruel comebacks. As viewers brace themselves to say goodbye once again to the beloved Will & Grace, let’s take a look back at some of Karen’s most memorable insults.

Click through the gallery above for 11 of Karen’s snappiest one-liners.

Will & Grace, Thursdays, 9:30/8:30c, NBC