Francis Benhamou marked her early career with roles in "The Bronx Is Burning" (2006-07), "Arranged" (2007) and the biopic drama "Neal Cassady" (2007) with Tate Donovan. Later, she acted in "Breaking Upwards" (2010), "Inside Amy Schumer" (Comedy Central, 2012-) and the Darien Sills-Evans drama "Big Words" (2013).
She also appeared in the Ken Duken romance "My Last Day Without You" (2013). More recently, Benhamou acted in the drama "Listen Up Philip" (2014) with Jason Schwartzman.